From Ohio History Central
In 1811, William Henry Harrison led an American army against Prophetstown. Tecumseh was seeking allies in the southern part of the United States. Although Tecumseh had asked his brother not to attack the Americans in his absence, the Prophet did attack. When Tecumseh returned, Prophetstown no longer existed. The natives had abandoned it, and Harrison had then destroyed it. Many of his followers, hungry and defeated, returned to their former villages. They were unwilling to assist Tecumseh in forming his confederation. Tecumseh did try to recreate his confederacy, but he had only limited success. Tecumseh's quest formally ended in 1813, with his death at the Battle of the Thames in the War of 1812.