From Ohio History Central
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The Treaty with the Wyandots is also known as the Treaty of Upper Sandusky. Along with several other treaties between Native Americans and the United States government during the first decades of the nineteenth century, this treaty marked the slow but gradual removal of native people to land west of the Mississippi River. This particular treaty resulted in the removal of the Wyandot from Ohio in 1843. The Wyandot Indians were the last group of Native Americans to formally relinquish their lands in Ohio and leave the state. The removal of the Wyandot opened up much of Ohio to settlement.