Sala Bosworth was one of Ohio's earliest artists. He was born on September 15, 1805, in Halifax, Massachusetts.
Bosworth's family moved to Ohio in 1816 and settled in Marietta. When Bosworth was twenty-two years old, he enrolled at the Pennsylvania Academy of Fine Arts and received his first formal training as an artist. After studying painting for several years, he returned to Marietta and specialized in painting portraits. Bosworth traveled across southeastern Ohio in a continuing search for paying customers. While Bosworth was best known for his portraits, he also painted landscapes of Marietta and the surrounding countryside. His paintings and drawings were featured in Samuel P. Hildreth's Pioneer History of the Ohio Valley.
Besides supporting himself through art, Bosworth also worked as the auditor of Washington County, Ohio from 1846 to 1854 and as Marietta's postmaster from 1861 to 1870. When his eyesight began to deteriorate, Bosworth opened a grocery store. He later retired to Cincinnati, Ohio, and died in that city in 1890.