George Sprague was Ohio's fourth Secretary of Agriculture. The Secretary of Agriculture served as the head of the Ohio State Board of Agriculture.
Sprague was born in 1820. Little is known of his early life. He studied medicine, and by 1852 Sprague resided in Seneca County, Ohio, where he helped form the Seneca County Physician's Society. In 1853, Sprague became Ohio's Secretary of Agriculture, a position that he held until 1856. Shortly after resigning as secretary, he moved to Iowa, where he began breeding short-horn cattle. To help him in this endeavor, Sprague formed the Ohio Stock Breeding association, which included financial backers for his Iowa venture. While in Iowa, Sprague also edited the Iowa Homestead.